Specific antigen(s) in sarcoidosis: a link to autoimmunity?
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چکیده
منابع مشابه
Specific antigen(s) in sarcoidosis: a link to autoimmunity?
The nature of the activating antigen, however, has been an enigma over decades of sarcoidosis research. The histological similarities between sarcoidosis and tuberculosis, and the usefulness of tuberculin preparations in the Mendel-Mantoux test, led to the search for an antigen-containing extract, and in the middle of the last century, the first “antigen” was isolated from the spleen cells of p...
متن کاملSarcoidosis and Thyroid Autoimmunity
Most of the studies have shown a higher risk for subclinical and clinical hypothyroidism, antithyroid autoantibodies [overall antithyroid peroxidase antibodies (TPOAb)], and in general, thyroid autoimmunity, overall in the female gender in patients with sarcoidosis (S). A significantly higher prevalence of clinical hypothyroidism and Graves' disease was also described in female S patients with ...
متن کاملThyroid function and autoimmunity in sarcoidosis: a case-control study.
AIM To evaluate thyroid function and the presence of antithyroid autoantibodies in patients with sarcoidosis, compared to patients with chronic obstructive pulmonary disease (controls). METHODS Sera were obtained from 26 patients (19 women and 7 men) with active sarcoidosis, age and sex matched to 26 patients with diagnosed chronic obstructive pulmonary disease. Baseline thyrotropin, total tr...
متن کاملViruses, cytokines, antigens, and autoimmunity.
To explain the pathogenesis of autoimmunity, we hypothesize that following an infection the immune response spreads to tissue-specific autoantigens in genetically predisposed individuals eventually determining progression to disease. Molecular mimicry between viral and self antigens could, in some instances, initiate autoimmunity. Local elicitation of inflammatory cytokines following infection ...
متن کاملHeat-shock proteins as antigens in autoimmunity.
Heat-shock proteins as antigens in autoimmunity Willem van Eden,* Els J. M. Hogervorst,* Marca H. M. Wauben,* Ruurd van der Zee,t and Claire, J. P. Boog* *Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan I, 8508 TD Utrecht, The Netherlands and +Department of Bacteriology, National Institute for Public Health and Environmental Hygi...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2016
ISSN: 0903-1936,1399-3003
DOI: 10.1183/13993003.01791-2015